Ultra-low dose (+)-naloxone restores the thermal threshold of morphine tolerant rats
نویسندگان
چکیده
منابع مشابه
Effect of ultra low dose morphine on seizure induced by pentylentetrazol
Introduction: In the Kindling-induced seizure model, low and repeated electrical or chemical stimulations, can elevate the neural network excitability and induce epileptiform seizures. Opioid receptors are widely distributed in different areas of the brain. On the other hand, morphine has paradoxical effects and induces elevation or alleviation of the pain sensation and excitability, at diff...
متن کامل[Involvement of the amygdala on place aversion induced by naloxone in single-dose morphine-treated rats].
Signs characteristic of opiate withdrawal symptoms can be precipitated by an opiate antagonist after short-term infusion or even a single dose of an opiate both in humans and in animals. This phenomenon has been referred to as acute dependence. In contrast to extensive studies on chronic dependence, less is known about the neural mechanisms mediating acute dependence. It will benefit the develo...
متن کاملUltra-low dose naltrexone attenuates chronic morphine-induced gliosis in rats
BACKGROUND The development of analgesic tolerance following chronic morphine administration can be a significant clinical problem. Preclinical studies demonstrate that chronic morphine administration induces spinal gliosis and that inhibition of gliosis prevents the development of analgesic tolerance to opioids. Many studies have also demonstrated that ultra-low doses of naltrexone inhibit the ...
متن کاملSeizurogenic Effects of Low-dose Naloxone in Tramadol Overdose
Tramadol is used in treatment of moderate to severe pain. Nowadays tramadol overdose is one of the common emergencies. Naloxone is an antagonist which is used as a first step of treatment in these patients. This study was designed to evaluate the seizurogenic effects of naloxone in tramadol overdose. A number of 124 patients with the diagnosis of tramadol overdose were divided to receive lo...
متن کاملFixed-ratio escape and avoidance-escape from naloxone in morphine-dependent monkeys: effects of naloxone dose and morphine pretreatment.
Lever pressing by rhesus monkeys was maintained by morphine injections during four equally spaced sessions each day. During other periods, lever pressing was maintained by timeout from a continuous naloxone infusion (escape), or by timeout from a stimulus that preceded naloxone injections, or termination of the injections (avoidance-escape). As naloxone dose increased in the escape procedure, r...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the Formosan Medical Association
سال: 2013
ISSN: 0929-6646
DOI: 10.1016/j.jfma.2013.11.007